Scientifica SliceScope Pro 1000 Electrophysiology Rig
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    Simultaneously image and photostimulate hundreds of individual cells in 3D, with precise targeting of cells across large areas of the brain. Introducing the HoloStim-3D.

    Scientifica SliceScope Pro 1000

    A full electrophysiology system for dual or single patch clamp recording. This package consists of the SliceScope microscope, motorised XY translation stage, two PatchStar manipulators and adjustable Post & Platform mounting systems for the manipulators and sample. Typically used for slice electrophysiology and fluorescent imaging, it is also available in in vivo configurations.

    Benefits

    Slimline upright microscope

    Easily place other equipment around your sample and configure the microscope for specific experimental needs.

    Super-smooth micromanipulators

    The PatchStar micromanipulators have 20 nm resolution for absolute positioning control and less than 1 µm drift in two hours for long term experiments.

    Fully adjustable post and platforms

    Made from high-quality steel and aluminium these ultra-stable platforms can easily be moved to any position desired to gain easy access to the sample.

    Modular and versatile

    Available in multiple configurations for in vivo and in vitro electrophysiology, with options for fluorescent and confocal microscopy.

    Multiphoton imaging options

    Future-proof your investment by choosing a system that can be upgraded to multiphoton imaging studies if your experimental requirements change.

    Extended Warranty

    For a limited time, the warranty of SliceScope Pro rigs has been extended to three years.

    Control options

    Control the focus, condenser, translation stage and micromanipulators from any of our remote control options.

    Alternatively use Scientifica’s LinLab software, developed specifically to control all of our motorised components and heating and perfusion elements.

    Downloads

    Download the SliceScope Pro brochure for more information.

    Testimonials

    ““[The SliceScope] has all the best optical qualities of a top-flight microscope, pared down to the absolute essentials needed for patch-clamp electrophysiology, and then rebuilt with many highly useful features"
    Professor Dimitri Kullmann, Institute of Neurology, UCL
    “Scientifica’s Slicescope Pro 1000 is the Porsche of Electrophysiology Systems”
    Dr. Aikeremu Ahemaiti in Dr. Malin Lagerstrom’s Lab, University of Uppsala, Sweden.

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    Hatch, R., Mendis, G., Kaila K., Reid, C., Petrou, S. (2017) Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex. Frontiers in Cellular Neuroscience.  https://doi.org/10.3389/fncel....

    Jurčić, N., Er‐Raoui, G., Airault, C., Trouslard, T., Wanaverbecq, N., & Seddik, R. (2018). GABAB receptors modulate Ca2+ but not G protein‐gated inwardly rectifying K+ channels in cerebrospinal‐fluid contacting neurones of mouse brainstem. The Journal of Physiology. 997(2), 531-651. https://physoc.onlinelibrary.w...

    Kolb, I., Stoy, W., Rousseau, E., Moody, O., Jenkins, A., & Forest, C. (2016). Cleaning patch-clamp pipettes for immediate reuse. Scientific Reports, 6(1). http://dx.doi.org/10.1038/srep...

    Mapelli, L., Gagliano, G., Soda, T., Laforenza, U., Moccia, F., & D'Angelo, E. (2016). Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. The Journal Of Neuroscience, 37(5), 1340-1351. http://dx.doi.org/10.1523/jneu...

    Masuho, I., Ostrovskaya, O., Kramer, G., Jones, C., Xie, K., & Martemyanov, K. (2015). Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Science Signaling, 8(405), ra123-ra123. http://dx.doi.org/10.1126/scis...

    Ogg, C M., Ross, J M., Bendahmane, M., & Fletcher, M L. (2018). Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation. Nature Communications, 9(1868). https://www.nature.com/article...

    Sutton, L., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., & Smith, R. et al. (2016). Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. Biological Psychiatry, 80(3), 235-245. http://dx.doi.org/10.1016/j.bi..

    Zecharia, A., Yu, X., Gotz, T., Ye, Z., Carr, D., & Wulff, P. et al. (2012). GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep-Wake Switch or Propofol-Induced Loss of Consciousness. Journal Of Neuroscience, 32(38), 13062-13075. http://dx.doi.org/10.1523/jneu...

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