Scientifica SliceScope Pro 2000 Electrophysiology Rig

The HyperScope multiphoton imaging system now has advanced imaging capabilities; the introduction of an extended wavelength lens set means you can image deeper and through thin scattering layers in in vivo samples. Learn more here.

Scientifica SliceScope Pro 2000

An integrated electrophysiology rig ideal for dual or single patch clamp recording with a movable microscope. This electrophysiology system consists of the SliceScope upright microscope, motorised XY translation stage, fixed-stage platform and two PatchStar motorised micromanipulators. The large plate allows the easy addition of extra manipulators or recording apparatus.


Incredibly stable fixed platform

A thick top and legs ensure excellent stability for long-term electrophysiology recordings and imaging experiments.

Slimline upright microscope

Easily place equipment around your sample and configure the microscope for specific experimental needs.

Super-smooth micromanipulators

The PatchStar micromanipulators have 20 nm resolution for absolute positioning control.

Ideal for network studies

Add extra manipulators to the large top plate to enable recordings from more than two electrodes for complex neuronal connection studies.

Extended Warranty

For a limited time, the warranty of SliceScope Pro rigs has been extended to three years.


The platform, with incorporated mounting carriages, gives flexibility for positioning manipulators and other equipment. There are also options for fluorescent microscopy and a variety of contrast techniques.

Control options

Control the focus, condenser, translation stage and micromanipulators from any of our remote control options.

Alternatively use Scientifica’s LinLab software, developed specifically to control all of our motorised components and heating and perfusion elements.


Download the SliceScope Pro brochure for more information.


“I'm so happy with the fact that for the next twenty years of my life, I will sit in front of the set-up which you have personalized us!”
Mr Richard König, University of Salzburg
“[The SliceScope] is highly stable and has a minimal footprint, clearly the result of listening to the experimenter's needs combined with clever design.”
Professor Dimitri Kullmann, Institute of Neurology, UCL
"I use the SliceScope Pro 2000 for both ex vivo and in vitro electrophysiological assessment. The adaptability of the SliceScope platform, the Molecular Devices Axon 1440A digitizer and 700B amplifier is highly appreciated. User serviceability of the system is high and Scientifica is always available to help out and solve any issues promptly."
Dr. Jon-Ruben van Rhijn, Donders Institute for Brain, Cognition and Behavior

Benevento, M., Iacono, G., Selten, M., Ba, W., Oudakker, A., & Frega, M. et al. (2016). Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling. Neuron, 91(2), 341-355.

Beyeler, A., Namburi, P., Glober, G., Simonnet, C., Calhoon, G., & Conyers, G. et al. (2016). Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval. Neuron, 90(2), 348-361.

Burgos-Robles, A., Kimchi, E., Izadmehr, E., Porzenheim, M., Ramos-Guasp, W., & Nieh, E. et al. (2017). Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment. Nature Neuroscience.

Dehorter, N., Ciceri, G., Bartolini, G., Lim, L., del Pino, I., & Marin, O. (2015). Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Science, 349(6253), 1216-1220.

Fyk-Kolodziej, B., Hellmer, C., & Ichinose, T. (2014). Marking cells with infrared fluorescent proteins to preserve photoresponsiveness in the retina. Biotechniques, 57(5).

Hellmer, C., Clemons, M., Nawy, S., & Ichinose, T. (2018). A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiological Reports. https://physoc.onlinelibrary.w...

Hellmer, C., Zhou, Y., Fyk-Kolodziej, B., Hu, Z., & Ichinose, T. (2016). Morphological and physiological analysis of type-5 and other bipolar cells in the Mouse Retina. Neuroscience, 315, 246-258.

Hellmer, C., Bohl, J., Hall, L., Koehler, C., & Ichinoise, T. (2020). Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells. Frontiers in Cellular Neuroscience.

Ichinose, T., & Hellmer, C. (2015). Differential signalling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina. The Journal Of Physiology, 594(4), 883-894.

Ichinose, T., Farshi, P., Fyk-Kolodziej, B., Krolewski, D., & Walker, P. (2015). Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina. The Journal Of Comparative Neurology, 524(10). Retrieved from

Ichinose, T., Fyk-Kolodziej, B., & Cohn, J. (2014). Roles of ON Cone Bipolar Cell Subtypes in Temporal Coding in the Mouse Retina. Journal Of Neuroscience, 34(26), 8761-8771.

Pougnet, J., Toulme, E., Martinez, A., Choquet, D., Hosy, E., & Boué-Grabot, E. (2014). ATP P2X Receptors Downregulate AMPA Receptor Trafficking and Postsynaptic Efficacy in Hippocampal Neurons. Neuron, 83(2), 417-430.

Vodeneev, V., Sherstneva, O., Surova, L., Semina, M., Katicheva, L., & Sukhov, V. (2016). Age-dependent changes of photosynthetic responses induced by electrical signals in wheat seedlings. Russian Journal Of Plant Physiology, 63(6), 861-868.

McIsaac, W., Ferguson, A V. (2017). Glucose concentrations modulate brain‐derived neurotrophic factor responsiveness of neurones in the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology, 29(4).


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