The HyperScope multiphoton imaging system now has advanced imaging capabilities; the introduction of an extended wavelength lens set means you can image deeper and through thin scattering layers in in vivo samples. Learn more here.
Scientifica PatchStar Micromanipulator
Perform in vivo and in vitro electrophysiology experiments with the highest precision using the most versatile motorised micromanipulator.
From positioning neural probes to patch clamp electrophysiology, this ultra-stable motorised micromanipulator can be configured around any setup, to suit your specific experiments and samples. The PatchStar is designed to precisely probe and record the smallest structures and signals, and is the ideal micromanipulator for demanding positioning requirements, such as microinjection, as well as long-term in vivo and in vitro electrophysiology recordings.
Perform sensitive recordings
You can detect even the quietest signals due to the low noise of the PatchStar. This enables you to perform sensitive recordings, such as single channel recordings, with ease.
Long-term recordings on small structures
With precise and stable movement, the PatchStar is ideal for long-term experiments on small structures, such as dendrites.
Easy to customise to your requirements
The modular design means there are various configurations available. The PatchStar can be easily switched between left and right-handed configuration, allowing it to be mounted on both sides of the sample.
The compact design of the PatchStar means you can easily mount your micromanipulator close to the sample.
Rotate the PatchStar with no need for tools; magnetic stops ensure the PatchStar is held in place whilst allowing it to be easily rotated away from your sample for pipette exchange, and then return to your precise recording position.
Effortlessly adjust your approach angle
The rotary stage and wide range of brackets available make it simple to adjust your approach angle and height to suit your application and sample. With automatic angle detection to easily change the angle of the 4th virtual axis
Simple and repeatable pipette exchange
Fast pipette movement and exchange is made easy by the sliding bracket and rotational stages. Your experiments won’t be held up and you can collect data faster. Memory positions held on the Controller or LinLab software can return the manipulator to a specific cell of interest if you need to replace your pipette mid experiment.
In vivo and in vitro
From in vivo multielectrode recordings to whole-cell patch clamp, you can perform a range of in vivo and in vitro experiments using the PatchStar.
The most versatile micromanipulator
Continuous developments based on customer feedback have enhanced the PatchStar and made it the ideal micromanipulator for a diverse range of applications, samples, and experiments. Each axis of the micromanipulator is an individual module, allowing you to easily reconfigure the PatchStar at any time, when your experimental needs change.
The sliding carriage enables a variety of headstages to be attached to the PatchStar. The range of brackets available, control options and software developments give you optimum flexibility. This is a micromanipulator that you can rely on.
Layer V pyramidal neurons in the V1 cortex acquired on a multipatch setup by Dr. Hovy Wong in the lab of Dr. Jesper Sjöström.
- Patch clamp electrophysiology
- In vivo electrophysiology
- Neural probe positioning
- Multielectrode recordings
- Extracellular/field recordings
- Intracellular/whole cell recordings
- Two-electrode voltage clamp
- Stimulation electrode
- Electrical engineering experiments
- Cell interaction studies
- Mechanical studies
- Scanning ion conductance microscopy
Intuitive control options and software
LinLab allows integration between Scientifica components or serial command codes can be provided for use with third party software. There are two speed settings available, which can be independently configured in the software and toggled between at the flick of a switch; fast speed for coarse positioning and patch speed for the final position.
"The compact shape of the PatchStar made it simple for me to install onto my existing rig. The movements of the PatchStar feel very smooth and the Control Cube allows me to easily gauge and adjust the speed of movement."Siyi Ma McMaster University
"The success rate of my outside-out patch clamp recordings significantly increased to over 90% or even 100%.”Dr Can Peng University of Florida
“We selected PatchStar micromanipulators for the combination of high precision, stability and competitive price.”Dr Roman Gorbachev The University of Manchester
“The PatchStar is the new standard. After 6-months of use, we are still truly impressed by the stability.”Dr Christophe Bernard Aix Marseille Université
"Since discovering the PatchStar, we have upgraded all of our nanoindentation setups to include it. The long travel range and high stability of the manipulator help us to reliably perform indentation measurements on a wide variety of samples without needing to make adjustments to the setup. This allows us to spend more time collecting data."Erik Paardekam VU University Amsterdam
"I started using the Patchstar system 10 years ago to perform in vivo dual recordings in Drosophila. Stability, versatility, and reliability are features we can’t compromise on; the Patchstar manipulators have certainly delivered. They now feature in all of the lab's electrophysiology rigs."Dr. Diogo Pimentel Centre for Neural Circuits and Behaviour, University of Oxford
"I would say that it is an incredibly stable and silent micro-manipulator which allows long-lasting recordings without mechanical drift or electrical noise."Dr. Julien Dupuis University of Bordeaux
"We purchased our first PatchStar because we liked the design and appreciated its excellent handling properties. It has been a great tool for our patch clamp experiments, which is why we have purchased nine other PatchStars since"Dr. Rob Roelfsema University of Würzburg
"They are incredibly precise and easy to use, really user friendly"Dr. Andrew Boyce University of Calgary
“We replaced an old faulty micromanipulator with the Patchstar with the aim of performing voltage clamp measurements on HEK293 cells. The Patchstar has performed very well, it is easy to use and very stable during the course of our measurements. A definite improvement to our setup!”Dr. Srividya Ganapathy Delft University of Technology
"Our research group has used the Scientifica PatchStar for many years and find it to be reliable, easy and intuitive to use for visually guided patch clamp. It gives us the fine control we need for patching multiple cells and maintaining those seals over long recordings."Hannah Warming University of Southampton
Customise the PatchStar to suit you
A wide range of accessories are available to adapt the PatchStar to your specific requirements. These include:
Allows low, shallow angle positioning of the headstage or probe (recommended if mounting on SlicePlatform, MTP or MMTP).
Shallow Bracket (PS-7500)
Allows steep angles or additional height reach for the headstage or probe (recommended if mounting on MMBP).
Steep Bracket (PS-7550)
Low Profile L Bracket
Allows the position of the Z axis module to be changed, lowering the height of the PatchStar for rigs with height restrictions.
Low Profile L Bracket (PS-7800)
Dovetail Probe Holder
For mounting a range of bars and probes.
Dovetail Probe Holder (PH-1000)
Electrode Holding Bar
With a v groove to hold glass capillaries.
Electrode Holding Bar (EHB-500).
Low-profile magnetic base to attach your PatchStar to your antivibration table or other platform.
Magnetic Base (S-MB-3020-00)
Sliding probe holder with a fixed angle of approach to mount stimulation bars, or headstages with mounting bar to PatchStar.
Fixed Sliding Probe Carriage (PS-7750)
Speak to one of our experts for details on pricing, features, installation and support.