Scientifica SliceScope Pro 1000 Electrophysiology Rig
Scientifica SliceScope Pro 1000
Overview Technical Data

Scientifica SliceScope Pro 1000

Standard System

We can customise this system to suit your unique experimental needs. Please contact us to discuss your requirements.

1 x Scientifica SliceScope

Slimline fully-motorised microscope

2 x Scientifica PatchStars

Perfect electrophysiology micromanipulator

2 x Scientifica Post & Platform Manipulator Mount
1 x Scientifica Motorised XY Stage

50 mm of travel

2 x Scientifica Control Devices

Choose from the Scientifica PatchPad or Control Cube

1 x Scientifica Sample Plate & Slice Recording Kit

Recording chamber & perfusion tools

Accessories

Scientifica Filter Cube Module

Collect higher quality data across the entire field of view with the Scientifica Filter Cube Module (FCM).

Scientifica SciCam Pro Camera

High resolution CCD camera specifically designed for use with electrophysiology setups. It is ideal for fluorescence imaging, live cell imaging, calcium imaging and electrophysiology.

Scientifica Motorised Objective Changer

The Scientifica Motorised Objective Changer can change smoothly between two objectives and display within LinLab which objective is in position. The user has full control over the speed of objective exchange.

Research Papers

  • High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.

    Korgan, A.C., Oliveira-Abreu, K., Wei, W. et al. High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight. (2023). International Journal Obesity 47, 224 - 235. https://doi.org/10.1038/s41366...

  • Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns.

    Vasile, F., Dossi, E., Moulard, J., Ezan, P., Lecoin, L., Cohen-Salmon, M., Mailly, P., Le Bert, M., Couillin, I., Bemelmans, A. and Rouach, N. Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns. PLOS Biology, (2022) https://doi:10.1371/journal.pbio.3001891.

  • Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala.

    Walter Francesconi, Fulvia Berton, Valentina Olivera-Pasilio, Joanna Dabrowska. (2021). Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala. Neuropharmacology, 192. https://doi.org/10.1016/j.neuropharm.2021.108601

  • GABAB receptors modulate Ca2+ but not G protein-gated inwardly rectifying K+ channels in cerebrospinal-fluid contacting neurones of mouse brainstem.

    Jurčić, N., Er-Raoui, G., Airault, C., Trouslard, J., Wanaverbecq, N. and Seddik, R. (2019). GABAB receptors modulate Ca2+ but not G protein-gated inwardly rectifying K+ channels in cerebrospinal-fluid contacting neurones of mouse brainstem. J Physiol, 597: 631-651. https://doi.org/10.1113/JP277172

  • Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex.

    Hatch Robert J., Mendis G. Dulini C., Kaila Kai, Reid Christopher A., Petrou Steven. Gap Junctions Link Regular-Spiking and Fast-Spiking Interneurons in Layer 5 Somatosensory Cortex. (2017). Frontiers in Cellular Neuroscience,11. https://doi.org/10.3389/fncel.2017.00204

  • Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System.

    Lisa Mapelli, Giuseppe Gagliano, Teresa Soda, Umberto Laforenza, Francesco Moccia, Egidio U. D'Angelo. Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System. (2017) Journal of Neuroscience, 37 (5) 1340-1351. https://doi.org/10.1523/JNEURO...

  • Cleaning patch-clamp pipettes for immediate reuse.

    Kolb, I., Stoy, W., Rousseau, E. et al. Cleaning patch-clamp pipettes for immediate reuse. (2016). Sci Rep 6, 35001. https://doi.org/10.1038/srep35...

  • Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors.

    Ikuo Masuho and Olga Ostrovskaya and Grant M. Kramer and Christopher D. Jones and Keqiang Xie and Kirill A. Martemyanov. (2015). Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors. Science Signaling, 8. DOI: 10.1126/scisignal.aab406

  • Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.

    Laurie P. Sutton, Olga Ostrovskaya, Maria Dao, Keqiang Xie, Cesare Orlandi, Roy Smith, Sunmee Wee, Kirill A. Martemyanov. (2015). Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. Biological Psychiatry, 8, 235-245. https://doi.org/10.1016/j.biopsych.2015.07.026

  • Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.

    Ogg, M.C., Ross, J.M., Bendahmane, M. et al. Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation. Nat Commun 9, 1868 (2018). https://doi.org/10.1038/s41467...

  • Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice.

    Robert John Hatch, Gerhard Leinenga, Jürgen Götz. Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice. (2016). PLOS ONE. https://doi.org/10.1371/journal.pone.0164278

  • Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight.

    Tiago Branco, Adam Tozer, Christopher J. Magnus, Ken Sugino, Shinsuke Tanaka, Albert K. Lee, John N. Wood, Scott M. Sternson. (2016). Near-Perfect Synaptic Integration by Nav1.7 in Hypothalamic Neurons Regulates Body Weight. Cell, 165, 1749-1761. https://doi.org/10.1016/j.cell...

  • Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate.

    Roberta de Ceglia, Linda Chaabane, Emilia Biffi, Andrea Bergamaschi, Giancarlo Ferrigno, Stefano Amadio, Ubaldo Del Carro, Nausicaa Mazzocchi, Giancarlo Comi, Veronica Bianchi, Stefano Taverna, Lia Forti, Patrizia D’Adamo, Gianvito Martino, Andrea Menegon, Luca Muzio. Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate. (2015). Brain, Behavior, and Immunity, 45, 263-276. https://doi.org/10.1016/j.bbi.....

  • Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model.

    Marcantoni, A., Raymond, E.F., Carbone, E. et al. Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model. (2014) Pflugers Arch - Eur J Physiol, 466, 1437–1450. https://doi.org/10.1007/s00424...

  • Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAA Receptors during Spillover.

    Damian P. Bright, Massimiliano Renzi, Julian Bartram, Thomas P. McGee, Georgina MacKenzie, Alastair M. Hosie, Mark Farrant and Stephen G. Brickley. (2011). Profound Desensitization by Ambient GABA Limits Activation of δ-Containing GABAA Receptors during Spillover. Journal of Neuroscience, 31 (2) 753-763. https://doi.org/10.1523/JNEURO...

  • Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B.

    Yan Jiang, Mira Jakovcevski, Rahul Bharadwaj, Caroline Connor, Frederick A. Schroeder, Cong L. Lin, Juerg Straubhaar, Gilles Martin and Schahram Akbarian. Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B. (2010). Journal of Neuroscience, 30 (21) 7152-7167. https://doi.org/10.1523/JNEURO...

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