Scientifica PatchStar Motorised Micromanipulator

Scientifica team members will be at the Imaging, Structure & Function in the Nervous System course at Cold Spring Harbour 25 July - 14 August.

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Scientifica PatchStar Micromanipulator

The most versatile motorised manipulator for electrophysiological studies. Designed with leading physiologists.



Less than 1 µm drift over 2 hours for long-term experiments

Super-smooth movement

20 nm resolution for absolute positioning


Easily switchable between left and right-handed configurations


Electrically quiet for recording of extremely small signals without having to switch off the motors

Fast & simple

Quickly move your pipette with adjustable speed settings and easily change pipettes thanks to the sliding bracket and rotational stages

PatchStar 360° view

Control options

Operate via our ergonomically designed remote control options or through our specially designed LinLab software.

Design & Specifications

3 orthogonal and 4th virtual
20 mm (in X, Y and Z axes)
Crossed roller
Minimum speed
Minimum speed
1 µm per second
Maximum speed
Maximum speed
4 mm per second
Electronic resolution
Electronic resolution
20 nm
Memory positions
Memory positions
50 on control device (unlimited via LinLab)
LinLab for Windows


“We selected PatchStar micromanipulators for the combination of high precision, stability and competitive price.”
Dr Roman Gorbachev, The University of Manchester
"The success rate of my outside-out patch clamp recordings significantly increased to over 90% or even 100%.”
Dr Can Peng, University of Florida
“The PatchStar is the new standard. After 6-months of use, we are still truly impressed by the stability.”
Dr Christophe Bernard, Aix Marseille Université


Download the PatchStar Micromanipulator brochure for more information.


Research Papers

Alfonsa, H., Lakey, J., Lightowlers, R., & Trevelyan, A. (2016). Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons. Nature Communications, 7, 13495.

Arends, F., Sellner, S., Seifert, P., Gerland, U., Rehberg, M., & Lieleg, O. (2015). A microfluidics approach to study the accumulation of molecules at basal lamina interfaces. Lab Chip, 15(16), 3326-3334.

Baheiraei, N., Gharibi, R., Yeganeh, H., Miragoli, M., Salvarani, N., Di Pasquale, E., & Condorelli, G. (2016). Electroactive polyurethane/siloxane derived from castor oil as a versatile cardiac patch, part II: HL-1 cytocompatibility and electrical characterizations. Journal Of Biomedical Materials Research Part A, 104(6), 1398-1407.

Bitzenhofer, S., Sieben, K., Siebert, K., Spehr, M., & Hanganu-Opatz, I. (2015). Oscillatory Activity in Developing Prefrontal Networks Results from Theta-Gamma-Modulated Synaptic Inputs. Cell Reports, 11(3), 486-497.

Bolding, K., & Franks, K. (2017). Complementary codes for odor identity and intensity in olfactory cortex. Elife, 6.

Brickley, S., Ye, Z., Yu, X., Houston, C., Aboukhalil, Z., Franks, N., & Wisden, W. (2017). Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits. Frontiers In Cellular Neuroscience, 11.

Chen, X., Bonfiglio, R., Banerji, S., Jackson, D., Salustri, A., & Richter, R. (2016). Micromechanical Analysis of the Hyaluronan-Rich Matrix Surrounding the Oocyte Reveals a Uniquely Soft and Elastic Composition. Biophysical Journal, 110(12), 2779-2789.

de Britto, A., & Moraes, D. (2017). Non-chemosensitive parafacial neurons simultaneously regulate active expiration and airway patency under hypercapnia in rats. The Journal Of Physiology, 595(6), 2043-2064.

Donghyun Hwang, Yong Seok Ihn, Seonhong Hwang, Sang-Rok Oh, & Keehoon Kim. (2016). A preliminary study on the method for stable and reliable implantation of neural interfaces into peripheral nervous system. 2016 6Th IEEE International Conference On Biomedical Robotics And Biomechatronics (Biorob).

Du, Y., Ma, B., Kiyoshi, C., Alford, C., Wang, W., & Zhou, M. (2015). Freshly dissociated mature hippocampal astrocytes exhibit passive membrane conductance and low membrane resistance similarly to syncytial coupled astrocytes. Journal Of Neurophysiology, 113(10), 3744-3750.

Edwards, I., Lall, V., Paton, J., Yanagawa, Y., Szabo, G., Deuchars, S., & Deuchars, J. (2014). Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits. Brain Structure And Function, 220(3), 1421-1436.

Funayama, K., Minamisawa, G., Matsumoto, N., Ban, H., Chan, A., & Matsuki, N. et al. (2015). Neocortical Rebound Depolarization Enhances Visual Perception. PLOS Biology, 13(8), e1002231.

Ghatak, S., Banerjee, A., & Sikdar, S. (2015). Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain. The Journal Of Physiology, 594(1), 59-81.

Leo-Macias, A., Agullo-Pascual, E., Sanchez-Alonso, J., Keegan, S., Lin, X., & Arcos, T. et al. (2016). Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc. Nature Communications, 7, 10342.

Leo-Macias, A., Agullo-Pascual, E., Sanchez-Alonso, J., Keegan, S., Lin, X., & Arcos, T. et al. (2016). Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc. Nature Communications, 7, 10342.

Linaro, D., Couto, J., & Giugliano, M. (2015). Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond. Journal Of Visualized Experiments, (100).

Ma, B., Xu, G., Wang, W., Enyeart, J., & Zhou, M. (2014). Dual patch voltage clamp study of low membrane resistance astrocytes in situ. Molecular Brain, 7(1), 18.

Ma, B., Xu, G., Wang, W., Enyeart, J., & Zhou, M. (2014). Dual patch voltage clamp study of low membrane resistance astrocytes in situ. Molecular Brain, 7(1), 18.

Mahmud, M., Cecchetto, C., & Vassanelli, S. (2016). An Automated Method for Characterization of Evoked Single-Trial Local Field Potentials Recorded from Rat Barrel Cortex Under Mechanical Whisker Stimulation. Cognitive Computation, 8(5), 935-945.

Maksaev, G., & Haswell, E. (2015). Expressing and Characterizing Mechanosensitive Channels in Xenopus Oocytes. Methods In Molecular Biology, 151-169.

Malik, R., & Ferguson, A. (2016). Hydrogen sulfide depolarizes neurons in the nucleus of the solitary tract of the rat. Brain Research, 1633, 1-9.

Meunier, C., Roberts, J., McCarty, G., & Sombers, L. (2017). Background Signal as an in Situ Predictor of Dopamine Oxidation Potential: Improving Interpretation of Fast-Scan Cyclic Voltammetry Data. ACS Chemical Neuroscience, 8(2), 411-419.

Nekolla, K., Kick, K., Sellner, S., Mildner, K., Zahler, S., & Zeuschner, D. et al. (2016). Influence of Surface Modifications on the Spatiotemporal Microdistribution of Quantum Dots In Vivo. Small, 12(19), 2641-2651.

Neto, J., Lopes, G., Frazão, J., Nogueira, J., Lacerda, P., & Baião, P. et al. (2016). Validating silicon polytrodes with paired juxtacellular recordings: method and dataset. Journal Of Neurophysiology, 116(2), 892-903.

Peterson, P., Kalda, M., & Vendelin, M. (2012). Real-time determination of sarcomere length of a single cardiomyocyte during contraction. American Journal Of Physiology - Cell Physiology, 304(6), C519-C531.

Ping, X., & Jin, X. (2016). Transition from Initial Hypoactivity to Hyperactivity in Cortical Layer V Pyramidal Neurons after Traumatic Brain InjuryIn Vivo. Journal Of Neurotrauma, 33(4), 354-361.

Rehberg, M., Nekolla, K., Sellner, S., Praetner, M., Mildner, K., Zeuschner, D., & Krombach, F. (2016). Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo. Small, 12(14), 1882-1890.

Roberts, A., Conte, D., Hull, M., Merrison-Hort, R., al Azad, A., & Buhl, E. et al. (2014). Can Simple Rules Control Development of a Pioneer Vertebrate Neuronal Network Generating Behavior?. Journal Of Neuroscience, 34(2), 608-621.

Sellner, S., Kocabey, S., Nekolla, K., Krombach, F., Liedl, T., & Rehberg, M. (2015). DNA nanotubes as intracellular delivery vehicles in vivo. Biomaterials, 53, 453-463.

Sellner, S., Kocabey, S., Nekolla, K., Krombach, F., Liedl, T., & Rehberg, M. (2015). DNA nanotubes as intracellular delivery vehicles in vivo. Biomaterials, 53, 453-463.

Shevchuk, A., Tokar, S., Gopal, S., Sanchez-Alonso, J., Tarasov, A., & Vélez-Ortega, A. et al. (2016). Angular Approach Scanning Ion Conductance Microscopy. Biophysical Journal, 110(10), 2252-2265.

Wong, C., & Mills, J. (2016). Cleavage-stage embryo rotation tracking and automated micropipette control: Towards automated single cell manipulation. 2016 IEEE/RSJ International Conference On Intelligent Robots And Systems (IROS).

Ye, Z., McGee, T., Houston, C., & Brickley, S. (2013). The contribution of δ subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex. Frontiers In Neural Circuits, 7.

Worldwide Presence

Scientifica’s equipment is used in more than 50 countries worldwide. Some of our customers include; California Institute of Technology, University of Oxford, Stanford University, University of Cambridge, Massachusetts Institute of Technology, Harvard University, Princeton University, Imperial College London, University of Chicago, Johns Hopkins University, Yale University and over 700 more research institutions.

2 Year Warranty

Scientifica offer a two-year warranty with all Scientifca manufactured goods and a one-year warranty for third party supplied goods. Giving you peace of mind when purchasing your Scientifica equipment.

Scientifica Exchange Programme

Scientifica Exchange gives you a convenient method for swapping your faulty equipment over for working instruments quickly, to keep you working even if something goes wrong.

In the event that a Scientifica product needs repairing or servicing then the faulty equipment may be exchanged for the same type of equipment from Scientifica’s service stock.

To ensure the service is fast and cost effective we will ship you the replacement part as soon as we can. Read more about the exchange programme here.


Shallow Bracket (PS-7500)

Allows low, shallow angle positioning of the headstage or probe (recommended if mounting on SlicePlatform, MTP or MMTP)

Shallow bracket (PS-7500) Shallow bracket (PS-7500)

Steep Bracket (PS-7550)

Allows steep angles or additional height reach for the headstage or probe (recommended if mounting on MMBP)

Steep Bracket (PS-7550) Steep Bracket (PS-7550)

Low Profile L Bracket (PS-7800)

Allows the position of the Z axis module to be changed, lowering the height of the PatchStar for rigs with height restrictions

Low profile L Bracket Low profile L Bracket

Dovetail Probe Holder (PH-1000)

Dovetail probe holder to fit a wide-range of bars and probes

Dovetail Probe Holder Dovetail Probe Holder

Electrode Holding Bar (EHB-500)

Electrode/probe holding bar with v groove to hold glass capillaries

Electrode holding bar

Magnetic Base (S-MB-3020-00)

Low-profile magnetic base to attach your PatchStar to your antivibration table or other platform

Patchstar magnetic base

Universal Rod Holder (PS-7600)

Rod holder to mount stimulation bars, or headstages with mounting bars to the PatchStar.

Universal Rod Holder Universal Rod Holder

Fixed Sliding Probe Carriage (PS-7750)

Sliding probe holder with a fixed angle of approach to mount stimulation bars, or headstages with mounting bar to PatchStar.

Fixed sliding probe carriage Fixed sliding probe carriage
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