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Scientifica IVM Single

A single axis motorised manipulator developed in collaboration with leading researchers for demanding in vivo applications.

Compatible with a wide range of stereotaxic arms and the LBM-7 manipulator for microinjection, electrophysiology and viral injections among other applications.

Benefits

Long travel

70 mm of travel to reach deep within your sample.

Ultra-stable design

Less than 1 µm drift over 2 hours for long-term experiments.

Super-smooth movement

20 nm resolution for absolute positioning.

Unique “creeper” function

Minimise tissue damage when penetrating deep into your sample by enabling your probe to "creep" to a desired position at a speed of your choice using the LinLab software.

Silent

Operate via our ergonomically designed remote control options or through our specially designed LinLab software.

Control options

Operate via our ergonomically designed remote control options or through our specially designed LinLab software.

Downloads

Download the IVM Single brochure for more information.

Design & Specifications

Number of axes
Number of axes
1
Travel distance
Travel distance
70 mm
Electronic resolution
Electronic resolution
20 nm
Minimum step size
Minimum step size
0.1 µm
Minimum speed
Minimum speed
1 µm per second
Maximum speed
Maximum speed
4 mm per second
Memory positions
Memory positions
50 on control device (unlimited via LinLab)
Software
Software
LinLab for Windows

Testimonials

"Compared to other micromanipulators I have used, the Scientifica IVM allows us to isolate more cells and to record from each cell for a longer time."
Dr Nicholas Lesica, Ear Institute, University College London

in vivo manipulatorin vivo manipulatorin vivo manipulator

References

Abdi, A., Mallet, N., Mohamed, F., Sharott, A., Dodson, P., & Nakamura, K. et al. (2015). Prototypic and Arkypallidal Neurons in the Dopamine-Intact External Globus Pallidus. Journal Of Neuroscience, 35(17), 6667-6688. http://dx.doi.org/10.1523/jneu...

Bocian, R., Kazmierska, P., Kłos-Wojtczak, P., Kowalczyk, T., & Konopacki, J. (2015). Orexinergic theta rhythm in the rat hippocampal formation: In vitro and in vivo findings. Hippocampus, 25(11), 1393-1406. http://dx.doi.org/10.1002/hipo...

Boutin, R., Alsahafi, Z., & Pagliardini, S. (2016). Cholinergic modulation of the parafacial respiratory group. The Journal Of Physiology, 595(4), 1377-1392. http://dx.doi.org/10.1113/jp27...

Devonshire, I., Greenspon, C., & Hathway, G. (2015). Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex. Neuroscience, 305, 343-350. http://dx.doi.org/10.1016/j.ne...

Devonshire, I., Kwok, C., Suvik, A., Haywood, A., Cooper, A., & Hathway, G. (2015). A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes. European Journal Of Neuroscience, 42(1), 1726-1737. http://dx.doi.org/10.1111/ejn....

Dodson, P., Dreyer, J., Jennings, K., Syed, E., Wade-Martins, R., & Cragg, S. et al. (2016). Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proceedings Of The National Academy Of Sciences, 113(15), E2180-E2188. http://dx.doi.org/10.1073/pnas...

Dodson, P., Larvin, J., Duffell, J., Garas, F., Doig, N., & Kessaris, N. et al. (2015). Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus. Neuron, 86(2), 501-513. http://dx.doi.org/10.1016/j.ne...

Doig, N., Magill, P., Apicella, P., Bolam, J., & Sharott, A. (2014). Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli. Journal Of Neuroscience, 34(8), 3101-3117. http://dx.doi.org/10.1523/jneu...

Ford, M., Alexandrova, O., Cossell, L., Stange-Marten, A., Sinclair, J., & Kopp-Scheinpflug, C. et al. (2015). Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing. Nature Communications, 6, 8073. http://dx.doi.org/10.1038/ncom...

Kazmierska, P., & Konopacki, J. (2015). Development of theta rhythm in hippocampal formation slices perfused with 5-HT1A antagonist, (S)WAY 100135. Brain Research, 1625, 142-150. http://dx.doi.org/10.1016/j.br...

Schweimer, J., Coullon, G., Betts, J., Burnet, P., Engle, S., & Brandon, N. et al. (2014). Increased burst-firing of ventral tegmental area dopaminergic neurons ind-amino acid oxidase knockout micein vivo. European Journal Of Neuroscience, 40(7), 2999-3009. http://dx.doi.org/10.1111/ejn....

Sharott, A., Doig, N., Mallet, N., & Magill, P. (2012). Relationships between the Firing of Identified Striatal Interneurons and Spontaneous and Driven Cortical Activities In Vivo. Journal Of Neuroscience, 32(38), 13221-13236. http://dx.doi.org/10.1523/jneu...

Zhang, C., Luo, W., Zhou, P., & Sun, T. (2016). Microinjection of acetylcholine into cerebellar fastigial nucleus induces blood depressor response in anesthetized rats. Neuroscience Letters, 629, 79-84. http://dx.doi.org/10.1016/j.ne...

Zhang, C., Sun, T., Zhou, P., Zhu, Q., & Zhang, L. (2015). Role of Muscarinic Acetylcholine Receptor-2 in the Cerebellar Cortex in Cardiovascular Modulation in Anaesthetized Rats. Neurochemical Research, 41(4), 804-812. http://dx.doi.org/10.1007/s110...

Accessories

Dovetail Probe Holder (PH-1000)

Dovetail probe holder to fit bars/probes

Dovetail probe holder

Extended Right Angled Kopf Mount (IVM-650-00)

Allows the user to mount the IVM in one of four mounting positions on the Kopf or Stoelting manipulator.

LBM-7 Adjustable Mount (IVM-510-00)

This allows the approach axis of the LBM-7 to be removed, enabling the IVM be mounted in its place. It can then be rotated and locked in position at the correct angle.

LBM-7 Fixed Mount (IVM-505-00)

Allows the user to mount the IVM on the LBM-7 either to the approach axis stage or to the sliding carriage attached to the approach axis. If mounted on the approach axis stage it can only do so in the same axis as the stage. If mounted on the sliding bracket it can be mounted at 90º or in the same axis as the approach axis.

Extended Probe Holder

To hold capillary glass of 1-2 mm in diameter.

Right Angled Kopf Mount (IVM-520-00)

Allows the user to mount the IVM in a single mounting position on the Kopf or Stoelting manipulator.

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