Meet our Customers: Suresh Kumar Jetti, Massachusetts Institute of Technology
At a recent event, we had the pleasure of catching up with Suresh Kumar Jetti, a Research Scientist at The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, to discuss his recent publication which utilised the Scientifica PatchStar Micromanipulator to advance the understanding of synaptic diversity mechanisms.
Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons
Key highlights from the study:
- Tonic and phasic motoneurons exhibit diversity in synaptic structure and output
- Isoform-Patch-seq highlights differentially regulated molecular pathways
- Genetic analyses identify regulators of Ca2+ buffering and AZ organization
- Differential ubiquitination and sialylation regulate synaptic growth and structure
Read the full paper
Meet our Customers: Suresh Kumar Jetti, MIT
About Suresh
Suresh Kumar Jetti obtained his PhD from KU-Leuven, Belgium, where he studied olfactory coding and the functional connectivity of habenula circuits using whole-cell patch-clamp physiology, two-photon calcium imaging, and optogenetics. He is working as a Research Scientist at the Picower Institute for Learning and Memory, MIT. He is studying molecular mechanisms of synapse diversity by combining his expertise in whole-cell patch-clamp physiology, calcium imaging, optogenetics, Patch-Seq RNA profiling, and STED nanoscopy. His research lies at the dynamic intersection of neural circuits and synaptic physiology.
For the past 13 years, the PatchStar has been my favourite equipment, enabling me to record challenging neurons from Zebrafish and Drosophila brains in vivo. Additionally, I utilised the PatchStar for conducting Patch-Seq RNA profiling from Drosophila motor neurons. I owe a debt of gratitude to the PatchStar for simplifying the execution of demanding patch-seq experiments from larval Drosophila motor neurons. I highly recommend the PatchStar for its reliability, user-friendliness, and precision.
Suresh Kumar Jetti Picower Institute for Learning and Memory, MIT
Scientifica PatchStar Micromanipulator
Perform in vitro and in vivo electrophysiology experiments with the highest precision using the most versatile motorised micromanipulator.
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