Postdoc Positions at the Hebrew University of Jerusalem

The HoloStim-3D seamlessly integrates with the HyperScope, an award-winning multiphoton imaging system, to create an industry-leading spatial light modulator (SLM) system for all-optical interrogation of neural networks with previously unachievable performance.

Employment start date: 1st September 2020

Contract length: Funding is available for four years and can be extended, if necessary.

Institution: Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem

Department: Department of Medical Neurobiology

The Position

We are seeking motivated Postdoctoral candidates to study luminance-dependent modulation of retinal function.

The mammalian retina maintains high sensitivity over an extraordinary range of luminance levels, ranging from starlight to bright sunlight. This is achieved by switching between the rod and cone systems, and within each system, by employing light adaptation mechanisms that preserve a contrast-invariant response. While dopamine is known to modulate retinal network activity in proportion to luminance, the luminance-dependent signals and the circuits that transmit them to elicit light adaptation, remain elusive. Our work identified a family of luxotonic amacrine cells in which activity increases with luminance level and are poised to modulate retinal function in a luminance-dependent manner. We determine the kinetics of the synaptic input to luxotonic amacrine cells, identify their pre- and postsynaptic partners, and test their role in retinal light adaptation. Implementing optogenetics, chemogenetics, functional imaging, whole-cell electrophysiology, and serial section electron microscopy, this study will help further our understanding of a fundamental adaptive mechanism in a key sensory modality.

The Candidates

Successful candidates will show solid communication skills in English, ability to work both independently and as part of a research team, strong scientific motivation, proved experience in patch-clamp electrophysiology, and skill in Matlab or python programming. Experience in optogenetics or two-photon imaging would be an advantage.

How to Apply

An application package, including a motivation letter, curriculum vitae, list of publications and names of 2-3 referees, should be sent to Dr. Shai Sabbah ([email protected]).

Contact information

Department of Medical Neurobiology

Faculty of Medicine

The Hebrew University of Jerusalem, Ein Kerem

P.O. Box 12271, Jerusalem, 9112102 Israel

Phone: +972-2-6758401

Email: [email protected]


Please mention that you saw this job on Scientifica's website when applying.

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