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Position: Postdoctoral Fellowship
Location: Upper Campus, University of Utah
The Stefan Pulst / Daniel Scoles Neurology Laboratory group at the University of Utah, Department of Neurology, invites applications for a postdoctoral fellowship for the study of cerebellar ataxia and other neurodegenerative diseases using calcium imaging and electrophysiological recordings. The Neurology Laboratory is well-funded by NIH, and other funding sources. We seek a highly motivated PhD in a related medical science who is interested in carrying out research on how RNA granules control localized calcium abundance and neuronal function in cultured cells and acute brain slices. The research objectives include understanding mechanisms of neurodegenerative disease as well as testing novel therapeutics in disease models.
The postdoc will join a well-established research program focused on developing therapeutics for cerebellar ataxia, amyotrophic lateral sclerosis, and other neurodegenerative disorders. The cellular mechanisms underlying these neurodegenerative diseases will be evaluated using a combination of two-photon imaging to monitor calcium abundance changes, live imaging for monitoring the movement of RNA granules, and electrophysiological recordings.
Located on the upper campus of the University of Utah, the position offers exceptional opportunities for interdisciplinary collaboration with a diverse group of investigators in both the Department of Neurology and the College of Pharmacy with a wide range of interests relative to the area of investigation, and a rigorous focus on developing therapeutics for neurodegenerative diseases.
The postdoc will plan, design, and conduct experiments that are related to the project. Experiments may involve classical cell and molecular biology techniques, cloning, transfection, cell culture assays, AAV gene delivery in mice, electrophysiological recordings, and two-photon imaging.
Applicants should be highly motivated, have a PhD and at least 1 year of experience with extracellular or patch-clamp electrophysiology in acute brain slices. Experience with two-photon imaging would be a plus. Other requirements include laboratory, analytical, and organizational skills, verbal and written communication skills, and the ability to work in a team.
Lab funding and selected publications
R37-NS033123, R01-NS097903, U01-NS103883, R21-NS081182, R21-NS103009, Michael J Fox Foundation, Harrington Discovery Institute.
1) Scoles et al. Antisense oligonucleotide therapy for spinocerebellar ataxia type 2. Nature 544:362-366; 2017.
2) Paul et al. Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Nature Commun 9(1):3648; 2018.
How to Apply
Please send applications to job post # PRN18147B at employment.utah.edu. Please direct all enquiries to [email protected]