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Position: Postdoc position at the Institute of Physiology, OVGU Magdeburg/Germany
Closing date: Open until filled
Position: Institute position, secured long-term funding
Contract: 2-6 years, depending on individual qualification
Starting date: negotiable
Institution: Otto-von-Guericke-University Magdeburg, Germany
Department: Institute of Physiology (Medical Faculty)
The Institute of Physiology at the Otto-von-Guericke-University Magdeburg (Head: Prof. Dr. Volkmar Lessmann) invites applications for a Postdoc position in cellular neuroscience.
We are looking for an ambitious Postdoc with a strong neurobiological background who is interested to explore the molecular mechanisms of synaptic plasticity by live-cell imaging and electrophysiological techniques. The successful candidate is expected to possess several years of experience with advanced cellular imaging techniques (e.g. using laser scanning microscopy, 2-photon imaging, STED) and data analysis. Expertise in electrophysiological methods (patch clamp, field potential recordings) and optogenetic techniques is also highly appreciated, but not absolutely required. The candidate should be highly motivated, pro-active and a responsible team member.
The lab investigates the cellular processes underlying learning and memory with a combination of electrophysiological and imaging techniques using slice preparations from hippocampus, amygdala, or neocortex as model systems. We are especially interested in the mechanisms by which secreted messengers like neuropeptides and growth factors trigger or modulate plasticity processes. In recent years, we have focused on the synaptic functions of Brain-derived neurotrophic factor (BDNF) and dopamine, successfully pinpointing their mechanistic contribution to different forms of plasticity (e.g. see Edelmann et al. , Neuron, 2015; Groessl et al., Nat. Neurosci., 2018). To gain even more insight, we want to visualize messenger secretion and function in parallel to the expression of synaptic plasticity using novel imaging tools. Moreover, behavioral physiology that delivers complementary data to our ex vivo electrophysiological and imaging experiments will allow us to directly delineate the importance of the identified molecular processes for learning and memory formation.
The lab offers state of the art equipment and instrumentation for:
- combined patch clamp recordings and fluorescence imaging in acute slices and dissociated cell cultures; optogenetic stimulation of neurons
- Morris water maze, fear conditioning, fear extinction, novel object recognition tasks for mice
- viral expression of proteins of interest (gene technology lab at level S2) and stereotactic injections
- morphological analysis of neurons and dendritic spines (Golgi-Cox staining)
- protein biochemistry and ELISA
Apart from institutional funding, our work is supported by grants from EU-Horizon 2020 (JPND project CircProt), the DFG (CRC 779; RTG 2413 Synage) and the ESF (ABINEP graduate school).
Our team of experienced electrophysiologists, imaging experts, behavioral pharmacologists and molecular biologists offers an excellent research environment, providing intensive support and inspiring scientific interactions.
Salary will be offered according to the German TV-L (100% E13) scheme. The position is provided by institutional funding and initially limited to 2 years. Prolongation is possible. Applicants are expected to hold a PhD degree in neuroscience (or in a closely related field) and should have proven their scientific excellence by a least one first author publication.
How to Apply
Please send your application via email to: Prof. Dr. Volkmar Lessmann ([email protected]). Only complete applications with all documents mentioned above in either English or German language will be considered. Only candidates selected for interviews will be contacted.
Contact information for informal questions
Prof. Dr. Volkmar Lessmann
Institute of Physiology
Otto-von-Guericke University Magdeburg
Leipziger Straße 44
39120 Magdeburg, Germany
e-mail: [email protected]