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Location: Plymouth, UK
The University of Plymouth are seeking a highly motivated PhD candidate with outstanding abilities and excited about studying neurodegenerative diseases like Parkinson’s disease.
The student must enjoy reading scientific papers, working in the laboratory with human and mouse tissue, and communicating experimental results in an international setting. Publications and previous experience in working on mouse models of neurodegenerative diseases are an advantage but not an essential prerequisite. Laboratory experience is essential. Interest and knowledge in electrophysiological recordings would be an additional benefit and would allow expanding the project. International students must also have an IELTS score of 7.0 or above (with no less than 6.5 in any element).
Recent preclinical data suggest that accumulation of the protein alpha-synuclein, which is also enriched in most PD patients, could reduce the amount of Ret receptor and thereby prevent GDNF’s cell survival function. We plan to investigate Ret protein levels in PD and Dementia with Lewy body (DLB) brains. Furthermore, we will investigate the effect of Ret, alpha-synuclein and other PD-related proteins on the midbrain dopaminergic system in mice (Aron et al., 2010; Meka et al., 2015; Kramer and Liss, 2015). The detailed phenotypic analysis of these transgenic mice will help us to define the molecular crosstalk between alpha-synuclein toxicity and Ret signalling and might allow proposing novel pathways to treat PD and DLB.
The studentship is supported for 3 years and includes full Home/EU tuition fees plus a stipend of an estimated £14,553 per annum. Applicants from overseas need to cover overseas fees (around £10610).
How to Apply
Follow the link https://www.plymouth.ac.uk/student-life/your-studies/the-graduate-school/applicants-and-enquirers and click ‘Apply’. Send application to the attention of Francesca Niedzielski.