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Position duration: 3 years
Start date: 1st April 2020
Institute: UK Dementia Research Institute at the University of Cambridge
A 3-year fully-funded PhD position is available through the Alzheimer's Society scheme in UK Dementia Research Institute at the University of Cambridge.
The project aims to identify the components of the intrinsic cellular machineries for handling aggregation-prone proteins, and characterise circumstances in which these machineries are activated, with the view to identifying new therapeutic targets to ameliorate/prevent the aggregation load in neuronal cells (associated with neurodegenerative diseases). The project stems from in-house developed technology enabling detection of failures in the protein-folding quality control system with high space-time resolution, and its ability to visualise the existence of the aggregation-resolving activity in live cells.
Student will develop the experimental models for monitoring protein quality control and aggregation in live iPSC-derived neurons, and analyse the activity of the intrinsic systems applying a range of biochemical, molecular biology and advanced light imaging techniques. Along with molecular biology/biochemistry, the work will involve training in light microscopy techniques such as Fluorescence Lifetime Imaging, super-resolution microscopy and single particle tracking using state of the art optics and software. This work will be conducted with support of interdisciplinary collaborators including physicists and computer scientists, enabling optical tools, mathematical modeling and data analysis.
The successful student will develop skills in biochemistry, cell biology, molecular biology, and advanced microscopy and image analysis. Students from disciplines other than biological sciences, who have a numeric aptitude and a strong interest in developing those skills are welcome to apply too (an academic background in mathematics, statistics, or computer science would be of interest).
The student will be based in the UK DRI, Department of Clinical Neuroscience, Clifford Allbutt Building, at the Cambridge Biomedical Campus. The supervisor's research group is an interdisciplinary team studying organelle biology in neuronal cell function and neurodegeneration, supported by a network of international and local collaborations.
Dr. Edward Avezov
Second supervisor: Prof. Giovanna Mallucci
Award type and eligibility:
Full studentships (UK/EU tuition fees and an enhanced stipend of £16,000.00 [tax-free] for 3 years for UK/EU students subject to eligibility criteria (below). Please read the eligibility criteria carefully before applying.
This is a fully funded, 3 -year PhD studentship commencing 1-April 2020.
To be enrolled on the PhD programme, applicants should have (or expect to obtain) at least 2:1 honours degree or equivalent.
Enquiries should be addressed to Dr. Edward Avezov at [email protected]
How to Apply
Applications should be made via the standard admissions procedure on the University's Graduate Admissions website (http://www.graduate.study.cam.ac.uk/how-do-i-apply ) please select Easter 2020 as the start term and PhD in Clinical Neurosciences as the course.
Please include Dr. Edward Avezov as the Supervisor's name on application and the reference number. There is no need for a research proposal but a brief summary of what you want to work on will be sufficient under "Research Summary".
Deadline for applications for this studentship is 14 January 2020. There is a fee of £65.00 to apply which is not refundable.
Interviews are likely during week commencing 10 February.
Any queries relating to the application process should be sent to Shannon Tinley- Browne at [email protected]
Please quote reference ZE21632 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.