npi electronics ELC-Series Universal Amplifier

Simultaneously image and photostimulate hundreds of individual cells in 3D, with precise targeting of cells across large areas of the brain. Introducing the HoloStim-3D.

npi electronic ELC-Series Universal Amplifier

Combining traditional patch and microelectrode recording with electrical stimulation, dye application or single cell transfection.

All ELC amplifiers enable an investigator to identify a single cell by its characteristic spike train and then electroporate or stimulate this cell in situ.

npi electronic ELC-Series Universal Amplifier
Allows investigations under more natural, non-invasive conditions

Using the loosepatch clamp technique for recording and stimulation in slice or in vivo preparations.

Experiments can be executed with minimal damage to individual cells

This also includes subcellular structures such as dendrites and axons.

Use the same pipette for several cells

No gigaseal is required for these types of experiments.

The ELC incorporates a unique headstage with a resistive-feedback circuit capable of functioning as follows:

Patch Clamp headstage with pA sensitivity

High-impedance electrometer with bridge balance capable of functioning as a conventional bridge amplifier

Extracellular amplifier with highpass and lowpass filters and gain up to 1000

ELC-03XS - Versatile All-in-One Amplifier

  • Recording with patch, sharp, metal or carbon fiber electrodes
  • In vivo recordings with miniature headstages
  • Extracellular recordings with high gain
  • Headstages with additional extracellular channels
  • Juxtasomal filling of dyes or DNA
  • Intracellular recording in CC (bridge) mode with patch or sharp electrodes
  • Intracellular recording in VC mode with patch electrodes
  • Single cell stimulation
  • Amperometry, voltammetry and iontophoresis
  • Improved series resistance compensation
  • Telegraph lines for filters and gains
  • Reliable recording from astrocytes
  • Compatible to all major data acquisition systems
  • Combined in vivo whole-cell patch-clamp recordings with extracellular multielectrode recordings with the NEURALYNX system

ELC-01X - Amplifier for Extracellular Recording and Electroporation

  • Recording with patch, sharp, metal or carbon fiber electrodes
  • In vivo recordings with miniature headstages
  • Extracellular recordings with high gain
  • Headstages with additional extracellular channels
  • Juxtasomal filling of dyes or DNA
  • Single cell stimulation
  • Iontophoresis
  • Intracellular recording in CC (bridge) mode with patch or sharp electrodes
  • Telegraph lines for filters and gains
  • Compatible to all major data acquisition systems

Pyramidal and Stellate Cell Specificity of Grid and Border Representations in Layer 2 of Medial Entorhinal Cortex

Neuron

View paper

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

Stem Cell Reports

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Anesthetized- and awake-patched whole-cell recordings in freely moving rats using UV-cured collar-based electrode stabilization

Nature Protocols

View paper

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