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Complete rigs SliceMaster
This yields two major benefits: This approach not only leads to a much higher throughput of data but, even more important, also optimises the use of animals. The use of animals in scientific procedures is an important public issue and it is regulated in almost every country. It is an important cost and prestige factor in today’s drug research (In the UK it is regulated by the Animals (Scientific Procedures) Act 1986, Europe (86/609-EEC) and the USA (NIH Publication 85-23, revised 1985). The regulations offer a high level of protection to animals whilst at the same time recognising the need to use animals in scientific research for the development of new medicines. The UK Animals (Scientific Procedures) Act is widely recognised as the strictest in the world and in some ways exceeds the European Union Directive (86/609/EEC) dealing with the welfare of laboratory animals. This UK Act will only allow research to be carried out using animals if any benefit the research is likely to bring outweighs any pain and distress the animals may suffer.
The UK Act states that, whenever possible, any strategy which minimises animal use, without compromising the quality of the scientific work should be pursued, consistent with the three Rs (reduction, refinement, replacement; Russell and Burch, 1959). The SliceMaster system allows electrophysiological recordings from multiple brain slices, both simultaneously and independently. The remote user console has been designed to facilitate operation by a sole individual and provides a means to conduct eight concurrent experiments, which would be physically impossible using conventional methods. In addition, the system provides data acquisition and analysis software, thereby increasing the user’s data-handling productivity to keep pace with the increase in data generation capacity.
The SliceMaster is available in three versions: the “full version” with eight recording sites, the “half” version with four recording sites and a “mini” version with two recording sites. This approach allows for the easy upgrade which means that a research team can explore the benefits of the SliceMaster approach before making a full investment or can add extra capacity as and when needed.
This yields two major benefits: This approach not only leads to a much higher throughput of data but, even more important, also optimises the use of animals. The use of animals in scientific procedures is an important public issue and it is regulated in almost every country. It is an important cost and prestige factor in today’s drug research (In the UK it is regulated by the Animals (Scientific Procedures) Act 1986, Europe (86/609-EEC) and the USA (NIH Publication 85-23, revised 1985). The regulations offer a high level of protection to animals whilst at the same time recognising the need to use animals in scientific research for the development of new medicines. The UK Animals (Scientific Procedures) Act is widely recognised as the strictest in the world and in some ways exceeds the European Union Directive (86/609/EEC) dealing with the welfare of laboratory animals. This UK Act will only allow research to be carried out using animals if any benefit the research is likely to bring outweighs any pain and distress the animals may suffer.
The UK Act states that, whenever possible, any strategy which minimises animal use, without compromising the quality of the scientific work should be pursued, consistent with the three Rs (reduction, refinement, replacement; Russell and Burch, 1959). The SliceMaster system allows electrophysiological recordings from multiple brain slices, both simultaneously and independently. The remote user console has been designed to facilitate operation by a sole individual and provides a means to conduct eight concurrent experiments, which would be physically impossible using conventional methods. In addition, the system provides data acquisition and analysis software, thereby increasing the user’s data-handling productivity to keep pace with the increase in data generation capacity.
The SliceMaster is available in three versions: the “full version” with eight recording sites, the “half” version with four recording sites and a “mini” version with two recording sites. This approach allows for the easy upgrade which means that a research team can explore the benefits of the SliceMaster approach before making a full investment or can add extra capacity as and when needed.
The modular amplifiers are housed in a 19” cabinet while the stimulus isolation units need 2 modular systems. All connections are made by standard shielded cables through a central breakout box located near the computer interfaces. These units, as well as the control units forthe micromanipulators and chamber heaters, are mounted in a central 19” rack. In the separate remote user console is a mini rack which houses the audio monitor and electrode resistance digital display as well as computer and camera monitors.
